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Are There Target Doses for REAGILA?

REAGILA comes in 4 different dose strength capsules (1.5 mg, 3 mg, 4.5 mg, and 6 mg) and all doses are effective in treating schizophrenia.

Dosing REAGILA

Switching to REAGILA

The ultimate goal in schizophrenia treatment is recovery, which encompasses symptom remission in addition to adequate self-care, improved social and vocational functioning, maintenance of treatment effects, and relapse prevention1.

Cross-titration when switching

    Patients with stable symptoms can undergo a slow titration schedule
    Patients with stable symptoms can undergo a slow titration schedule

    References

    1. Durgam, S. et al. An evaluation of the safety and efficacy of cariprazine in patients with acute exacerbation of schizophrenia: A phase II, randomized clinical trial. Schizophr. Res. 152, 450–457 (2014).
    2. Durgam, S. et al. Cariprazine in acute exacerbation of schizophrenia: A fixed-dose, phase 3, randomized, double-blind, placebo- and active-controlled trial. J. Clin. Psychiatry 76, e1574-82 (2015).
    3. Kane, J. M. et al. Efficacy and Safety of Cariprazine in Acute Exacerbation of Schizophrenia: Results from an International, Phase III Clinical Trial. J. Clin. Psychopharmacol. 35, 367–373 (2015).
    4. Németh, G. et al. Cariprazine versus risperidone monotherapy for treatment of predominant negative symptoms in patients with schizophrenia: a randomised, double-blind, controlled trial. Lancet 389, 1103–1113 (2017).
    5. Stahl, S. M. Stahl ’ s Essential Psychopharmacology: Prescriber’s Guide. (Cambridge University Press, 2017).

    Essential Psychopharmacology: Prescriber’s Guide, 6th edition
    Dr. Stephen Stahl
    “Switching from Oral Antipsychotics to Cariprazine: Clinical experience has shown that asenapine, quetiapine, and olanzapine should be tapered off slowly over a period of 3-4 weeks, to allow patients to readapt to the withrawal of blocking cholinergic, histaminergic, and alpha 1 receptors. Clozapine should always be tapered off slowly, over a period of 4 weeks or more. “
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    STARTING DOSES FOR REAGILASTARTING DOSES FOR OUR PRODUCT

    REAGILA is indicated for the treatment of schizophrenia in adult patients. This covers all types of symptoms of schizophrenia, including positive, negative, cogFind out more about the starting doses from first episode to relapse

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    REAGILA AND DRUG INTERACTIONSCARIPRAZINE AND DRUG INTERACTIONS

    Cariprazine is metabolized into 2 pharmacologically active moieties: desmethyl cariprazine (DCAR) and didesmethyl cariprazine (DDCAR). This metabolism is mediatCariprazine is metabolized into 2 pharmacologically active moieties: desmethyl cariprazine (DCAR) and didesmethyl cariprazine (DDCAR). This metabolism is mediat

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    Contact Med Info

    If you have any questions about REAGILA, you can contact our Medical Information team.

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